Biophysics and Molecular Materials

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Lukas Milles

M.Sc. Lukas Milles


Lehrstuhl für Angewandte Physik
und Center for NanoScience
Amalienstr. 54
80799 München

Room: 002
Phone: +49 (0) 89/ 2180-3194
Fax: +49 (0) 89/ 2180-2050


  1. L. F. Milles, E. M. Unterauer, T. Nicolaus & H. E. Gaub,
    Calcium stabilizes the strongest protein fold
    Nature Communications, November 2018, DOI: 10.1038/s41467-018-07145-6
  2. L. F. Milles, K. Schulten, H. E. Gaub & R . C. Bernardi,
    Molecular mechanism of extreme mechanostability in a pathogen adhesin
    Science, Mar 2018, DOI: 10.1126/science.aar2094 PDF
  3. M. S. Bauer, L. F. Milles, S. M. Sedlak & H. E. Gaub,
    Monomeric streptavidin : a versatile regenerative handle for force spectroscopy
    bioRxiv preprint, Mar 2018, DOI: 10.1101/276444
  4. S. M. Sedlak, M. S. Bauer, C. Kluger, L. C. Schendel, L. F. Milles, D. A. Pippig & H. E. Gaub,
    Monodisperse measurement of the biotin-streptavidin interaction strength in a well-defined pulling geometry
    PLOS One, Dec 2017, DOI: 10.1371/journal.pone.0188722 PDF
  5. W. Ott* , M. A. Jobst* , M. S. Bauer, E. Durner, L. F. Milles, M. A. Nash & H. E. Gaub,
    Elastin-like Polypeptide Linkers for Single-Molecule Force Spectroscopy
    ACS Nano Jun 2017, DOI: 10.1021/acsnano.7b02694 PDF
  6. U. Brand, S. Gao, W. Engl, T. Sulzbach, S. W. Stahl, L. F. Milles, V. Nesterov & Z. Li,
    Comparing AFM Cantilever Stiffness Measured Using the Thermal Vibration and the Improved Thermal Vibration Methods with that of an SI Traceable Method Based on MEMS
    Meas. Sci. Technol., Jan 2017, DOI: 10.1088/1361-6501/28/3/034010
  7. L. F. Milles, E. A. Bayer, M. A. Nash & H. E. Gaub,
    Mechanical Stability of a High-Affinity Toxin Anchor from the Pathogen Clostridium Perfringens
    Journal of Physical Chemistry B, Nov 2016, DOI: 10.1021/acs.jpcb.6b09593 PDF
  8. M. A. Jobst, L. F. Milles, C. Schoeler, W. Ott, D. B. Fried, E. A. Bayer, H. E. Gaub, & M. A. Nash,
    Resolving dual binding conformations of cellulosome cohesin-dockerin complexes using single-molecule force spectroscopy
    eLife, Oct 2015, DOI: 10.7554/eLife.10319 PDF
  9. F. Baumann, M. S. Bauer, L. F. Milles, A. Alexandrovich, H. E. Gaub, & D. A. Pippig,
    Monovalent Strep-Tactin for strong and site-specific tethering in nanospectroscopy
    Nature Nanotechnology, Oct 2015, DOI: 10.1038/nnano.2015.231 PDF
  10. D. Aschenbrenner, F. Baumann, L. F. Milles, D. A. Pippig & H. E. Gaub,
    C-5 Propynyl Modifications Enhance the Mechanical Stability of DNA
    ChemPhysChem, May 2015, DOI: 10.1002/cphc.201500193 PDF
  11. K. Klamecka, P. M. Severin, L. F. Milles, H. E. Gaub & H. Leonhardt,
    Energy profile of nanobody–GFP complex under force
    Physical Biology, Sept 2015, DOI: 10.1088/1478-3975/12/5/056009 PDF
  12. C. Schoeler* , K. H. Malinowska* , R . C. Bernardi, L. F. Milles, M. A. Jobst, E. Durner, W. Ott, D. B. Fried, E. A. Bayer, K. Schulten, H. E. Gaub & M. A. Nash,
    Ultrastable cellulosome-adhesion complex tightens under load
    Nature Communications, Dec 2014, DOI: 10.1038/ncomms6635 PDF
  13. M. Otten* , W. Ott* , M. A. Jobst* , L. F. Milles, T. Verdorfer, D. A. Pippig, M. A. Nash & H. E. Gaub,
    From genes to protein mechanics on a chip
    Nature Methods Sept 2014, DOI: 10.1038/nmeth.3099 PDF
  14. K. H. Malinowska* , T. Verdorfer* , A. Meinhold, L. F. Milles, V. Funk, H. E. Gaub & M. A. Nash,
    Redox-Initiated Hydrogel System for Detection and Real-Time Imaging of Cellulolytic Enzyme Activity
    ChemSusChem, Aug 2014, DOI: 10.1002/cssc.201402428 PDF

* equal contribution